Papaemmanuil, M. Cazzola, J. Boultwood, L. Malcovati, P. Vyas, D. Bowen, A. Pellagatti, J.S. Wainscoat, E. Hellstrom-Lindberg, C. Gambacorti-Passerini, A.L. Godfrey, I. Rapado, A. Cvejic, R. Rance, C. McGee, P. Ellis, L.J. Mudie, P.J. Stephens, S. McLaren, C.E. Massie, P.S. Tarpey, I. Varela, S. Nik-Zainal, H.R. Davies, A. Shlien, D. Jones, K. Raine, J. Hinton, A.P. Butler, J.W. Teague, E.J. Baxter, J. Score, A. Galli, M.G. Della Porta, E. Travaglino, M. Groves, S. Tauro, N.C. Munshi, K.C. Anderson, A. El-Naggar, A. Fischer, V. Mustonen, A.J. Warren, N.C.P. Cross, A.R. Green, P.A. Futreal, M.R. Stratton, and P.J. Campbell for the Chronic Myeloid Disorders Working Group of the International Malignancy Genome Consortium: Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts The myelodysplastic syndromes certainly are a heterogeneous group of hematologic cancers characterized by low blood counts, most commonly anemia, and a risk of progression to acute myeloid leukemia.1 These disorders possess increased in prevalence and so are expected to continue to do so.10 Apart from TET2, many of these genes are mutated in no more than 5 to 15 percent of cases, and usually the mutation prices are lower in the more benign subtypes of the condition.So, if there is a shortage of B5, there exists a shortage of Coenzyme-A. And when there is a shortage of Coenzyme-A, the physical body will use it to synthesize sex hormones, not breakdown fatty acids. So, you can see where that is going more fatty acids, more sebum production, more acne. Now, the interesting thing is that Dr. Lit Hung Leung substantiated this state by examining it on 100 people. The group had taken 10 grams or even more each day of pantothenic acid , and utilized a B5 topical cream of 20 percent by weight. After 2-3, sebum creation was reduced, and several people who have acne noticed a decrease.