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This work was also published on the web in advance of print publication. An abstract of this paper and a web link to the free full-text article is available through PubMed. View abstract and link.. Advancing nanoparticle-centered therapy and imaging of mind cancer Brain cancer is one of the most challenging malignancies to detect and treat, in large part due to the difficulty in obtaining imaging and therapeutic agents past the so-called blood-mind barrier and into the brain. Several sets of investigators have found that nanoparticles hold guarantee for ferrying such agents into the brain , and now two new papers released in the Journal of Pharmacology and Experimental Therapeutics offer additional wish that nanotechnology may yield important advances in detecting and treating mind cancer.