The single-plex cells assay is a practical option to immunohistochemistry , a widely used assay that is frequently complicated because antibodies are either unavailable or unreliable in the experimental system under investigation. The QuantiGene ViewRNA Assay uses a novel oligonucleotide probe design that can be universally put on any gene of interest. Related StoriesPublic policy had a need to decrease stem cell tourism, state expertsKey protein settings stem cell properties that will make them useful in regenerative medicineResearchers determine inherited gene variation associated with pediatric severe lymphoblastic leukemia’In drug discovery, time is certainly of the essence, and this assay allows us to know earlier in the process whether or not a compound is promising more than enough to pursue,’ stated Dan Garza, Senior Director of Biology at Proteostasis Therapeutics, Inc., which happens to be using the assay to display screen proteostasis modulators.Then Hong and his team tested these substances for their results on zebrafish embryonic development. We quickly discovered that the two ramifications of dorsomorphin could possibly be separated – some analogs just affected patterning plus some just affected angiogenesis, Hong said. The investigators biochemically characterized compounds of both types and discovered very selective and powerful BMP inhibitors and selective VEGF inhibitors. Related StoriesDifferences in vitamin D status may take into account disparities in breast tumor survival ratesResearchers successfully fix nerve cell harm in Alzheimer's dementiaNew clinical trial uses aggressive treatment method for sufferers with pancreas cancerThe zebrafish embryo, Hong said, is very good in assessing a compound’s selectivity for a particular signaling pathway.