Aduro receives $442.

Aduro’s live-attenuated Listeria vaccine platform provides been evaluated in three Stage 1 medical trials. Aduro provides performed an initial analysis of long-term survival data resulting from one of these clinical studies, utilizing the Listeria strain CRS-207, that was engineered to express Mesothelin, an antigen commonly over-expressed in a range of solid tumors. The CRS-207 Phase 1 safety trial examined 17 patients with late-stage, mesothelin-expressing tumors: 7 pancreatic, 5 mesothelioma, 3 non-little cell lung, and 2 ovarian. Preliminary evaluation of long-term survival data exposed that multiple patients survived significantly longer than historical controls.The technology, recognized at the NIH’s National Heart, Blood and Lung Institute, shows that nitrite, which is transformed by the body into nitric oxide, could be delivered as a highly effective treatment for pulmonary hypertension, myocardial infarction, transplantation and cerebral vasospasm. Aires Pharmaceuticals can be developing Aironite, a proprietary, inhalable formulation of nitrite, to take care of pulmonary arterial hypertension . The business has Orphan Drug Status from the U.S.