With it’s substantial pool of patients, centralized healthcare program and motivated investigators it still offers time extremely, cost and quality advantages over other territories. This event will build upon our prior meetings by examining at length the current clinical landscape impacting medical trials in the CEE & CIS regiondealing with longstanding regulatory obstacles, site selection and performance hurdles, methods to ensure the quality and integrity of data and improving knowledge of clinical trials amongst the region’s human population. Particular attention may also be given to the continuing barriers to improvements in EU member says and also Russia, Ukraine and the Balkan regions via focused conference periods. NextLevel Pharma’s Clinical Site Partnerships in Central & Eastern Europe event may be the only meeting which provides the opportunity to participate in 1 on 1 partnering sessions enabling trial sponsor companies, CROs, clinical solution providers, and sites themselves to meet up with one another to discuss potential partnerships.The PRNP Y145X mutation has been described in a single affected person with an Alzheimer-type dementia and prion protein amyloid deposition in the cerebral vessels,5 the Q160X mutation has been referred to in a small family with dementia,6 and two C-terminal truncation mutations have been linked to the GSS syndrome in the event reviews.7 Here we explain the scientific, pathological, and molecular features of a large kindred with a consistent and novel prion disease phenotype that is connected with chronic diarrhea and hereditary sensory and autonomic neuropathy caused by a novel PRNP mutation. Methods Patients The proband donated his brain to the Queen Square Mind Bank for Neurological Disorders, London, for research in to the cause of his family’s neuropathy.